Preheat your oven to 350°F (175°C).

In a large bowl, combine the ground beef, breadcrumbs, chopped onion, and milk.

Add the egg, 2 tablespoons of ketchup, Worcestershire sauce, garlic powder, salt, and black pepper.

Mix until everything is well combined, but do not overmix.

Shape the mixture into a loaf and place it in a greased baking dish.

Spread 1/4 cup of ketchup over the top of the meatloaf for glaze.

Bake in the preheated oven for about 1 hour or until the internal temperature reaches 160°F (70°C).

Remove from the oven and let it rest for 10 minutes before slicing.

Serve warm with your favorite sides.

Enjoy your delicious meatloaf!