Preheat the oven to 400°F (200°C).
Mix buttermilk with garlic powder, onion powder, paprika, salt, and pepper in a bowl.
Add chicken pieces to the buttermilk mixture, ensuring they are well-coated.
In another bowl, place breadcrumbs.
Dredge each chicken piece in the breadcrumbs.
Place the coated chicken on a baking sheet lined with parchment paper.
Spray the chicken lightly with cooking spray.
Bake for 40-45 minutes, turning halfway through.
Ensure the internal temperature reaches 165°F (75°C).
Let the chicken rest for a few minutes before serving.