Marinate the chicken tenderloins in buttermilk for at least 30 minutes.
Preheat the air fryer to 400°F (200°C) for about 5 minutes.
Combine breadcrumbs, garlic powder, onion powder, paprika, salt, and pepper in a shallow dish.
Remove the chicken from the buttermilk and dredge in the breadcrumb mixture.
Lightly spray the air fryer basket with cooking spray.
Place the coated tenders in the air fryer in a single layer.
Cook for 10-12 minutes, flipping halfway through.
Check for an internal temperature of 165°F (75°C) for doneness.
Serve hot with your favorite dipping sauce.